KR-67607, also known as NTX-101 is novel selective 11beta-hydroxysteroid dehydrogenase 1 (11beta-HSD1) inhibitor. KR-67607 decreased 4-hydroxynonenal expression and increased antioxidant and mucus secretion in BAC-treated rat eyes. KR-67607 showed its protective effects against ischemia-reperfusion-induced eye injury. KR-67607 effectively reduced cortisol levels in mouse eyes and maintained the trabecular meshwork (TM) structure in the presence of transient ischemic stress. Furthermore, KR-67607 reversed the elevation of intra-ocular pressure (IOP), suggesting that the TM structure maintained by KR-67607 prevented the excessive rise in IOP that exacerbates glaucoma.
Molekulargewicht:
597.48
CAS Nummer:
[1401564-00-8]
Formel:
C24H29Cl2F3N4O4S
Target-Kategorie:
Others
T70763
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