SPR519 is a potent dual inhibitor of PI3Kalpha and mTOR kinases with IC50 (PI3Kalpha) = 30 nM and IC50 (mTOR) = 10 nM. SPR519 exhibits an EC50 of low sub-micromolar range among various tested cancer cell lines such as A2780 (0.23 µM), PC3 (0.48 µM), and SKOV3 (0.50 µM).
Molekulargewicht:
427.48
CAS Nummer:
[1391923-59-3]
Formel:
C19H21N7O3S
Target-Kategorie:
Others
T70792
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