M3541 is a selectively potent and orally active ATM inhibitor with potential antitumor activity.M-3541 inhibits ATM kinase activity and ATM-mediated signaling by binding to ATM.M3541 prevents activation of DNA damage checkpoints, inhibits DNA damage repair, contributes to apoptosis, and induces death of ATM overexpressing tumor cells.
Molekulargewicht:
428.42
Reinheit:
99.47%
CAS Nummer:
[1360628-91-6]
Formel:
C23H17FN6O2
Target-Kategorie:
ATM/ATR|||Apoptosis
T70873
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