PT-S58 is a PPAR beta/delta full antagonist, and a derivative of GSK0660. PT-S58 has a three-fold higher affinity for the receptor than GSK0660 and is a potent inhibitor of agonist-induced target gene expression. PT-S58 are effective on PPRE-independent functions of PPARbeta/delta. Unlike GSK0660, PT-S58 blocks the recruitment co-repressor molecules such as SMRT.
Molekulargewicht:
398.5
CAS Nummer:
[1356497-92-1]
Formel:
C17H22N2O5S2
Target-Kategorie:
Others|||PPAR
T70886
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