Bizelesin is a synthetic cyclopropylpyrroloindole antineoplastic antibiotic. Bizelesin binds to the minor groove of DNA and induces interstrand cross-linking of DNA, thereby inhibiting DNA replication and RNA synthesis. Bizelesin also enhances p53 and p21 induction and triggers G2/M cell-cycle arrest, resulting in cell senescence without apoptosis.
Molekulargewicht:
815.7
CAS Nummer:
[129655-21-6]
Formel:
C43H36Cl2N8O5
Target-Kategorie:
Others|||DNA Alkylator/Crosslinker
T71034
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