GSK1842799 is a selective S1P1 receptor agonist for multiple sclerosis. Upon phosphorylation, GSK1842799 showed subnanomole S1P1 agonist activity with >1000* selectivity over S1P3. GSK1842799 demonstrated good oral bioavailability. On the basis of the favorable in vitro ADME and in vivo PK/PD properties as well as broad toxicology evaluations, GSK1842799 was selected as a candidate for further clinical.
Molekulargewicht:
504.4342
CAS Nummer:
[1277165-15-7]
Formel:
C20H30Cl2F3N3O2S
Target-Kategorie:
Others|||Endogenous Metabolite
T71069
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