6-[2-(Diethylamino)ethyl]-10,11-dihydro-1H-dicyclopenta[c,g]carbazole-3,9(2H,6H)-dione (ACI) , CBL 0100 free base , CBL0100 free base , Curaxin 100 , 1H-Dicyclopenta[c,g]carbazole-3,9(2H,6H)-dione, 6-[2-(diethylamino)ethyl]-10,11-dihydro- (ACI)
CBL 0100 free base is an HIV-1 transcription inhibitor that blocks HIV-1 replication and reactivation in vitro and in ex vivo models. It targets the chromatin-associated transcription (FACT) complex, reducing the occupancy of RNA Polymerase II and FACT in the HIV-1 promoter region, and can be used as a latency-reversing agent (LRA) in cART therapy.
Molekulargewicht:
374.48
Reinheit:
98.86%
CAS Nummer:
[1197996-83-0]
Formel:
C24H26N2O2
Target-Kategorie:
HIV Protease|||Others|||DNA/RNA Synthesis
T71263
T71263
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