Gemfibrozil-D6 is intended for use as an internal standard for the quantification of gemfibrozil by GC- or LC-MS. Gemfibrozil (T1415) is a peroxisome proliferator-activated reporter alpha and PPARgamma agonist. In vivo, gemfibrozil reduces serum total cholesterol, triglyceride, and LDL levels in a rat model of high-cholesterol diet-induced hyperlipidemia. Gemfibrozil (T1415) reduces atherosclerotic plaque area, superoxide production, and expression of the genes encoding the NF-kappaB subunit p65 and chemokine (C-C) motif ligand 2 (CCL2) in ApoE-/- mice. Formulations containing gemfibrozil have been used in the treatment of high cholesterol.
Molekulargewicht:
256.37
CAS Nummer:
[1184986-45-5]
Formel:
C15H16D6O3
Target-Kategorie:
Cytochromes P450|||PPAR
T71306
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
