Patidegip, laos known as Saridegib and IPI-926, is an orally bioavailable, cyclopamine-derived (for structure comparison see Fig 1) inhibitor of the Hedgehog (Hh) pathway with potential antineoplastic activity. Specifically, Hedgehog pathway inhibitor IPI-926 binds to and inhibits the cell membrane-spanning G-protein coupled receptor SMO, which may result in the suppression of Hh pathway signaling and a decrease in tumor cell proliferation and survival. SMO is activated upon binding of Hh ligand to the cell surface receptor Patched (PTCH), inappropriate activation of Hh signaling and uncontrolled cellular proliferation may be associated with SMO mutations.
Molekulargewicht:
541.23
CAS Nummer:
[1169829-40-6]
Formel:
C29H49ClN2O3S
Target-Kategorie:
Others|||Smo
T71338
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