RO5126946 is a Novel alpha7 nicotinic acetylcholine receptor-positive allosteric modulator. RO5126946 allosterically modulates alpha7nAChR activity. RO5126946 increased acetylcholine-evoked peak current and delayed current decay but did not affect the recovery of alpha7nAChRs from desensitization. In addition, RO5126946s effects were absent when nicotine-evoked currents were completely blocked by coapplication of the alpha7nAChR-selective antagonist methyl-lycaconitine.
Molekulargewicht:
408.9
CAS Nummer:
[1137233-79-4]
Formel:
C19H21ClN2O4S
Target-Kategorie:
Others
T71398
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