Enadoline (Free Base) is a kappa-opioid receptor agonist, PD 129290 (CAM 570, CI 977) is the S,S(-)-enantiomer, PD 129289 (CAM 569) is the corresponding R,R(+)-enantiomer. In human studies, it produced visual distortions and feelings of dissociation, reminiscent of the effects of salvinorin A. It was studied as a potential analgesic, but abandoned because of the dose-limiting effects of dysphoria, which could be expected from a kappa-opioid agonist. There was mention of its potential in treating comatose head injury or stroke victims, where that type of side effect would be immaterial.
Molekulargewicht:
396.52
CAS Nummer:
[107431-28-7]
Formel:
C24H32N2O3
Target-Kategorie:
Others|||Opioid Receptor
T71491
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