DNJNAc, also known as 2-Acetamido-1,2-dideoxynojirimycin, is a highly potent and specific inhibitor of beta-hexosaminidase (HEX). HEX enzymes catalyze the hydrolysis of terminal non-reducing N-acetyl-beta-D-glucosamine (GlcNAc) and N-acetyl-beta-D-galactosamine (GalNAc) residues from glycoconjugates such as glycoproteins, gangliosides, and glycosaminoglycans. HEX secreted by chondrocytes into the extracellular space contributes to cartilage matrix degradation, and HEX activity is elevated in the synovial fluid of osteoarthritis patients.
Molekulargewicht:
204.22
Reinheit:
98.65%
CAS Nummer:
[105265-96-1]
Formel:
C8H16N2O4
Target-Kategorie:
glycosidase|||Hexokinase
T71525
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