SIM010603, CAS [[1032265-67-0]]
Artikelnummer:
TGM-T71576
| Artikelname: |
SIM010603, CAS [[1032265-67-0]] |
| Artikelnummer: |
TGM-T71576 |
| Hersteller Artikelnummer: |
T71576 |
| Alternativnummer: |
TGM-T71576-25MG,TGM-T71576-50MG,TGM-T71576-100MG |
| Hersteller: |
TargetMol |
| Kategorie: |
Biochemikalien |
| SIM010603 is a structurally novel, oral, multi-targeted receptor tyrosine kinase inhibitor. SIM010603 inhibited stem cell factor receptor (Kit), vascular endothelial growth factor receptor-2 (VEGFR-2), platelet-derived growth factor receptor-beta (PDGFR-beta), glial cell line-derived neurotrophic factor receptor (Rearranged during Transfection, RET), and Fms-like tyrosine kinase-3 (FLT3) with IC(50) values between 5.0 and 68.1 nmol/l. SIM010603 inhibited the phosphorylation of PDGFR-beta and VEGFR-2. Moreover, SIM010603 inhibited endothelial cell proliferation, endothelial cells chemotaxis, and corneal angiogenesis. |
| Molekulargewicht: |
396.46 |
| CAS Nummer: |
[1032265-67-0] |
| Formel: |
C22H25FN4O2 |
| Target-Kategorie: |
Others|||c-RET|||VEGFR|||c-Kit |
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T71576 |
