Z-VAE(OMe)-fmk is a cell-permeable and irreversible UCHL1 inhibitor. The inhibitor approaches the active-site cleft from the opposite side of the crossover loop as compared to the direction of approach of ubiquitins C-terminal tail, thereby occupying the P1 (leaving group) site, a binding site perhaps used by the unknown C-terminal extension of ubiquitin in the actual in vivo substrate(s) of UCHL1.
Molekulargewicht:
481.51
CAS Nummer:
[1027141-02-1]
Formel:
C23H32FN3O7
Target-Kategorie:
Others
T71586
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