6(5H)-Phenanthridinone, CAS [[1015-89-0]]

Produktübersicht

• Artikelname: 6(5H)-Phenanthridinone, CAS [[1015-89-0]]
• Artikelnummer: TGM-T72017
• Hersteller Artikelnummer: T72017
• Alternativnummer: TGM-T72017-1MG,TGM-T72017-5MG,TGM-T72017-10MG,TGM-T72017-25MG
• Hersteller: TargetMol
• Kategorie: Biochemikalien

Produktbeschreibung

6(5H)-Phenanthridinone is an inhibitor of poly(ADP-ribose) polymerase 1 (PARP1) and PARP2. It decreases radiation-induced PARP activity and proliferation of RDM4 murine lymphoma cells. 6(5H)-Phenanthridinone reduces NF-kappaB-induced transcription of the genes encoding TNF-alpha, IL-2, and IFN-gamma in rat lymphocytes. In vivo, 6(5H)-phenanthridinone reduces spinal cord expression of inducible nitric oxide synthase (iNOS), IL-1beta, TNF-alpha, IL-2, and IFN-gamma and reduces disease score in a rat model of experimental autoimmune encephalomyelitis (EAE). It also decreases serum levels of lactate dehydrogenase as well as hepatic lipid peroxidation, oxidative DNA damage, and PARP levels.

Produkteigenschaften

• Molekulargewicht: 195.22
• CAS Nummer: [1015-89-0]
• Formel: C13H9NO
• Target-Kategorie: Others|||PARP

Bilder

T72017