MTK458 (EP-0035985) is an orally active and brain-permeable PINK1 activator that promotes pathological clearance of alpha-synuclein and reduces pUb in a PFF inoculation model.MTK458 induces pathological alpha-synuclein clearance by stimulating dimerization and stabilization of the PINK1/TOM complex.MTK458 may be used in Parkinsons disease research.
Molekulargewicht:
332.32
Reinheit:
98.36%
CAS Nummer:
[2499962-58-0]
Formel:
C17H15F3N4
Target-Kategorie:
Mitochondrial Metabolism|||PTEN|||Mitophagy
T72420
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