SIRT6 activator 12q is a potent, selective, and orally active compound that activates SIRT6. It demonstrates IC50 values of 171.20 µM for SIRT1, >200 µM for SIRT2, SIRT3, and SIRT5, and 0.58 µM for SIRT6, indicating its high specificity towards SIRT6. This compound effectively inhibits cell growth and migration, induces apoptosis, and causes cell cycle arrest at the G2 phase, showcasing its anticancer activity.
Molekulargewicht:
454.52
Reinheit:
98.53%
CAS Nummer:
[2601734-99-8]
Formel:
C31H22N2O2
Target-Kategorie:
Apoptosis|||Others|||Sirtuin
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