GPR84 Antagonist 2, a potent and selective GPR84 antagonist (IC 50 = 8.95 nM), demonstrates oral activity and significantly enhances potency in calcium mobilization assays. It effectively inhibits neutrophil and macrophage chemotaxis following GPR84 activation, highlighting its research potential for ulcerative colitis.
Molekulargewicht:
605.42
CAS Nummer:
[2244269-74-5]
Formel:
C28H16Cl2NaO4PS2
Target-Kategorie:
GPCR|||Others
T72536
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