NKP-1339 free base , IT-139 free base , NKP-1339 free base , IT-139 free base , KP-1339 free base , KP-1339 free base
BOLD-100 free base (NKP-1339, IT-139), a ruthenium-based anticancer agent, inhibits stress-induced GRP78 upregulation, thus disrupting endoplasmic reticulum (ER) homeostasis. This action induces ER stress and unfolded protein response (UPR), interfering with the intricate relationship between ER-stress response, lysosome dynamics, and autophagy execution.
Molekulargewicht:
479.15
CAS Nummer:
[783324-98-1]
Formel:
C14H12Cl4N4Ru
Target-Kategorie:
Autophagy|||HSP|||Others
T72543
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