Antitumor agent-81, a P62-RNF168 agonist with low cytotoxicity, enhances the P62-RNF168 interaction, leading to decreased RNF168-mediated H2A ubiquitination and impaired homologous recombination-mediated DNA repair. Additionally, it exhibits dose-dependent inhibition of xenograft tumor growth in mice.
Molekulargewicht:
393.4
CAS Nummer:
[2765180-17-2]
Formel:
C19H19N7O3
Target-Kategorie:
Others|||p62|||Apoptosis|||E1/E2/E3 Enzyme
T72560
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