Isoandrographolide is a minor diterpene lactone compound and also an in vivo metabolite with multiple pharmacological activities. It alleviates pulmonary inflammation and tissue damage in silicosis models by inhibiting the activation of the NLRP3 inflammasome. It significantly inhibits the release of key inflammatory mediators such as lipopolysaccharide-induced nitric oxide (NO), prostaglandin E2 (PGE2), and interleukin-1beta (IL-1beta) in various inflammatory cell models while also demonstrating potential tumor suppression properties.
