A2AR-antagonist-1 (compound 38), an orally active adenosine A2A receptor antagonist with an IC50 value of 29 nM, demonstrates anti-tumor properties and stability in mouse liver microsomes (t1/2 = 86.1 min). Additionally, it activates T cells by inhibiting immunosuppressive molecules (LAG-3 and TIM-3) and promoting expression of effector molecules (GZMB, IFNG, and IL-2) [1].
Molekulargewicht:
451.52
CAS Nummer:
[2922920-71-4]
Formel:
C27H25N5O2
Target-Kategorie:
Adenosine Receptor
T72626
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