NMDAR/TRPM4-IN-2 is a potent interfacial inhibitor of NMDAR/TRPM4 interaction.NMDAR/TRPM4-IN-2 protects against MCAO-induced brain damage and NMDA-induced retinal ganglion cell loss in mice.NMDAR/TRPM4-IN-2 has neuroprotective activity against NMDA-induced hippocampal neuronal cell death and mitochondrial dysfunction. NMDAR/TRPM4-IN-2 showed neuroprotective activity against NMDA-induced cell death and mitochondrial dysfunction in hippocampal neurons with an IC50 value of 2.1 µM.
Molekulargewicht:
330.092
Reinheit:
99.75%
CAS Nummer:
[2243506-33-2]
Formel:
C11H19BrCl2N2
Target-Kategorie:
iGluR|||NMDAR|||ERK|||TRP/TRPV Channel
T72662
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