sEH/AChE-IN-3 (15) serves as a dual inhibitor targeting both soluble epoxide hydrolase (sEH) and acetylcholinesterase (AChE), demonstrating potent activity and the ability to cross the blood-brain barrier (BBB). It exhibits IC50 values of 0.4 nM for human sEH (hsEH), 1.94 nM for human AChE (hAChE), 615 nM for human butyrylcholinesterase (hBChE), 4.3 nM for mouse sEH (msEH), and 2.61 nM for mouse AChE (mAChE), indicating its efficacy across these enzymes.
Molekulargewicht:
670.16
CAS Nummer:
[2490589-11-0]
Formel:
C35H39ClF3N5O3
Target-Kategorie:
Others|||Cholinesterase (ChE)|||Epoxide Hydrolase
T72875
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