eIF4A3-IN-17, a silvestrol analogue, disrupts the assembly of the eIF4F translation complex, exhibiting EC50 values of 0.9, 15, and 1.8 nM for myc-LUC, tub-LUC, and growth inhibition of MBA-MB-231 cells, respectively. This compound holds potential for research in human cancer pathogenesis [1].
Molekulargewicht:
487.5
CAS Nummer:
[1402931-75-2]
Formel:
C28H25NO7
Target-Kategorie:
PERK|||Others
T72943
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