(S)-V-0219, an enantiomer of V-0219, is an orally active positive allosteric modulator (PAM) of the GLP-1 Receptor (GLP-1R). It activates calcium fluxes in HEK cells stably expressing hGLP-1R, demonstrating its oral activity. Additionally, (S)-V-0219 ameliorates high glucose levels in mice and inhibits feeding behavior in fasted mice [1].
Molekulargewicht:
410.43
Formel:
C20H25F3N4O2
Target-Kategorie:
Others|||Glucagon Receptor
T73081
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