SMTIN-T140 (compound 6a), a potent TRAP1 (tumor-necrosis-factor-receptor associated protein 1) inhibitor with an IC50 of 1.646 µM, exhibits anticancer activity by inducing mitochondrial dysfunction, elevating mitochondrial ROS production, and activating AMPK. Notably, SMTIN-T140 effectively suppressed tumor growth without discernible in vivo toxicity in a PC3 prostate cancer cell-xenografted mouse model [1].
Molekulargewicht:
718.02
CAS Nummer:
[2851532-40-4]
Formel:
C36H34BrClFN5OP+
Target-Kategorie:
Reactive Oxygen Species|||HSP|||AMPK
T73125
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