DOCK2-IN-1, an analogue of CPYPP, effectively inhibits DOCK2 (IC50 = 19.1 µM) by reversibly binding to its DHR-2 domain, thereby hindering its catalytic function. This compound obstructs the activation of Rac in lymphocytes, triggered either by chemokine or antigen receptors. Consequently, DOCK2-IN-1 markedly reduces chemotactic responses and T cell activation [1].
Molekulargewicht:
298.72
CAS Nummer:
[4590-86-7]
Formel:
C16H11ClN2O2
Target-Kategorie:
Others
T73194
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