OTS193320, an imidazopyridine compound, acts as an inhibitor of SUV39H2 methyltransferase activity. It effectively reduces global histone H3 lysine 9 tri-methylation levels in breast cancer cells, promoting apoptotic cell death. When combined with Doxorubicin (DOX), OTS193320 enhances the reduction of gamma-H2AX levels and decreases cancer cell viability more significantly than when either agent is used alone.
Molekulargewicht:
536.02
CAS Nummer:
[2093401-33-1]
Formel:
C28H30ClN5O4
Target-Kategorie:
Apoptosis|||Histone Methyltransferase|||Others
T73225
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