CPT-Se3, a camptothecin (CPT) seleno-derivative, exhibits enhanced anticancer efficacy by effectively killing cancer cells and hindering tumor proliferation. This compound diminishes the GSH/GSSG ratio and total thiols while increasing ROS levels, ultimately triggering apoptosis in Hep G2 cells. Furthermore, CPT-Se3 demonstrates significant cytotoxicity against HeLa, Hep G2, A549, and SMMC-7721 cell lines with IC50 values ranging from 2.19 to 4.7 µM [1].
Molekulargewicht:
590.35
CAS Nummer:
[2968315-02-6]
Formel:
C24H20N2O6Se2
Target-Kategorie:
Topoisomerase|||Apoptosis
T73421
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