RI-962 is a potent and selective inhibitor of RIPK1 that dose-dependently protects cells from necrotic apoptosis induced by TNFalpha, Smac mimics, and Z-VAD-FMK by inhibiting RIPK1, RIPK3, and MLKL phosphorylation with EC50=10.0 nM~17.8 nM, and improves survival in mice in two models of inflammation.
Molekulargewicht:
480.56
Reinheit:
99.39%
CAS Nummer:
[2763831-53-2]
Formel:
C28H28N6O2
Target-Kategorie:
RIP kinase
T73493
T73493
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