TNG260 is a selective and orally effective inhibitor of HDAC1 and the CoREST complex, exhibiting 10-fold selectivity for HDAC1 over HDAC3 and 500-fold selectivity for CoREST over NuRD and Sin3 complexes. TNG260 reshapes the tumor immune microenvironment by reducing immunosuppressive neutrophil infiltration, enhancing effector T-cell recruitment, reversing anti-PD-1 resistance driven by STK11 deficiency, and inducing durable tumor regression in combination with alpha-PD-1 in STK11-mutant MC38 tumor models while maintaining lower bone marrow toxicity than non-selective HDAC inhibitors.
Molekulargewicht:
383.44
Reinheit:
99.78%
CAS Nummer:
[2935964-98-8]
Formel:
C20H18FN3O2S
Target-Kategorie:
HDAC
T73520
T73520
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
