GK563, a selective Ca 2+-independent phospholipase A2 (GVIA iPLA2) inhibitor, exhibits a potent IC50 value of 1 nM and demonstrates 22,000-fold greater activity against GVIA iPLA2 compared to GIVA cPLA2. Its efficacy in reducing beta-cell apoptosis triggered by proinflammatory cytokines suggests potential therapeutic benefits in combating autoimmune disorders, including type 1 diabetes.
Molekulargewicht:
246.34
CAS Nummer:
[2351820-19-2]
Formel:
C16H22O2
Target-Kategorie:
Apoptosis|||Phospholipase|||Others
T73527
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