JB170 is a highly efficient and specific Aurora A degradator (DC50 = 28 nM). The PROTAC is composed of Alisertib and Thalidomide, with an EC50 value for AURORA-A that is ten times that of AURORA-B. It induces S-phase arrest in cell growth and inhibits the non-catalytic function of the AURORA-A kinase.
Molekulargewicht:
963.36
Reinheit:
99.82%
CAS Nummer:
[2705844-82-0]
Formel:
C48H44ClFN8O11
Target-Kategorie:
PROTACs|||Aurora Kinase
T74174
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