JPS014, a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimera (PROTAC), effectively degrades class I histone deacetylase (HDAC), exhibiting potency as an HDAC1/2 degrader. This correlation is associated with an increase in differentially expressed genes and enhanced apoptosis in HCT116 cells [1].
Molekulargewicht:
854.07
CAS Nummer:
[2669785-76-4]
Formel:
C46H59N7O7S
Target-Kategorie:
PROTACs|||Others|||HDAC
T74453
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