ITK Degrader 1, a highly selective interleukin-2-inducible T-cell kinase (ITK, DC50=3.6 nM in vivo in mice) degrader, induces rapid and prolonged degradation of ITK and effectively suppresses IL-2 secretion (EC50=35.2 nM, Jurkat cells) stimulated by anti-CD3 antibody in vivo. Additionally, it demonstrates favorable plasma exposure levels [1].
Molekulargewicht:
943.02
Formel:
C48H57F3N10O7
Target-Kategorie:
Others|||Tyrosine Kinases|||PROTACs
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
