FXR agonist 3 is an anti-NASH compound with antifibrotic and anti-fibrotic activity, inhibiting the expression of COL1A1, TGF-beta1, alpha-SMA, and TIMP1, with an IC50 value of 8.19 µmol/L for COL1A1. FXR agonist 3 ameliorates CDAHFD and BDL-induced liver injury in vivo by activating FXR.
Molekulargewicht:
521.12
Reinheit:
95.04%
Formel:
C28H28BrNO4
Target-Kategorie:
FXR|||Others
T74996
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