ELA-32(human) TFA is a potent apelin receptor agonist with high affinity, demonstrating an IC50 of 0.27 nM and a Kd of 0.51 nM. This compound does not bind to GPR15 or GPR25. It activates the PI3K/AKT signaling pathway, facilitating self-renewal of human embryonic stem cells (hESCs) through cell-cycle progression and protein synthesis. Additionally, ELA-32(human) TFA enhances the TGFbeta pathway, predisposing hESCs towards an endoderm lineage, and promotes angiogenesis in HUVEC cells.
Molekulargewicht:
4081.84
Formel:
C172H290F3N63O41S4
Target-Kategorie:
Apelin receptor
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