(Glu2)-TRH, a metabolically stable analogue of Thyrotropin-releasing hormone (TRH), acts as a negative modulator of TRHs cholinergic effect in the mouse brain, significantly reducing TRH-induced release of extracellular acetylcholine in the hippocampus. Resistant to metabolism by thyroliberinase, (Glu2)-TRH exhibits neuroprotective, antidepressant, and anticonvulsant properties in the CNS [1].