Adintrevimab (ADG20) is a broad-spectrum neutralizing monoclonal antibody targeting SARS-CoV-2. It binds to a highly conserved epitope within the receptor-binding domain (RBD) of the spike glycoprotein, blocking its interaction with the ACE2 receptor. The Fc region is modified to extend its in vivo half-life. Research demonstrates potent neutralizing activity against various variants including Alpha, Beta, Gamma, and Delta, although its activity is significantly reduced against certain Omicron sub-lineages.
CAS Nummer:
[2516243-54-0]
Target-Kategorie:
SARS-CoV
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