TT-012 has anti-tumor activity, selectively binds dynamic MITF and disrupts the dimer formation and DNA binding of the latter. TT-012 can inhibit the transcription of MITF in B16F10 melanoma cells. TT-012 inhibited the growth and metastasis of MITF melanoma cells in animal models. TT-012 is less cytotoxic to liver and immune cells.
Molekulargewicht:
349.34
Reinheit:
0.9994
CAS Nummer:
[1164471-33-3]
Formel:
C19H15N3O4
Target-Kategorie:
Others
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