Dothiepin (Dosulepin, Dothep), an antidepressant with sedative/anxiolytic properties, preferentially inhibits noradrenaline over serotonin uptake, enhancing noradrenergic neurotransmission by blocking neuronal reuptake. Additionally, it acts as a histamine H1-receptor antagonist and lacks cardiotoxicity. Its analgesic efficacy is noted in conditions such as psychogenic facial pain, idiopathic fibromyalgia syndrome, and rheumatoid arthritis [1].
Molekulargewicht:
295.44
CAS Nummer:
[113-53-1]
Formel:
C19H21NS
Target-Kategorie:
Histamine Receptor|||5-HT Receptor
T78126
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