RET-IN-22 (compound 17b) is a potent, selective, and orally active inhibitor of RET, exhibiting IC50 values of 20.9 nM for wild-type RET and 18.3 nM for RET-V804M. It demonstrates a highly selective inhibition profile across a broad spectrum of kinases, with notable specificity over EGFR and VEGFR2, and is implicated in exerting anticancer effects [1].
Molekulargewicht:
584.59
CAS Nummer:
[2918281-79-3]
Formel:
C29H31F3N6O4
Target-Kategorie:
c-RET|||Others
T78683
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