PI3Kdelta-IN-12 (compound 13), a PI3Kdelta inhibitor with a pIC50 of 5.8, exhibits differential binding affinities with pKi values of 8.0 for PI3Kdelta, 6.5 for PI3Kgamma, 6.4 for PI3Kbeta, and 6.7 for PI3Kalpha. This compound is used in researching chronic respiratory conditions, including asthma and chronic obstructive pulmonary disease (COPD) [1].
Molekulargewicht:
444.27
Formel:
C20H15Cl2N5O3
Target-Kategorie:
PI3K
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