MS78, an acetylation targeting chimera (AceTAC), specifically acetylates the p53Y220C mutant by recruiting the histone acetyltransferase p300/CBP. This compound enhances the expression of TRAIL apoptotic genes while concurrently suppressing DNA damage response pathways. Its structure comprises a CBP/p300 binding domain, a p53Y220C targeting moiety, and a connecting linker [1].
Molekulargewicht:
1024.25
Formel:
C57H66FN9O6S
Target-Kategorie:
Others|||MDM-2/p53|||Histone Acetyltransferase
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