Compound 114 (D3R/MOR antagonist 1) exhibits dual antagonistic activity at dopamine D3 receptors (D3R) and mu-opioid receptors (MOR), with K i values of 46.5 nM and 691 nM, respectively. It offers analgesic benefits through partial agonism at MOR and may decrease the risk of opioid misuse through its D3R antagonistic properties [1].
Molekulargewicht:
420.38
Formel:
C22H27Cl2N3O
Target-Kategorie:
Dopamine Receptor|||Opioid Receptor
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