NDNA3 (compound 14) selectively inhibits Hsp90alpha with an IC50 of 0.51 µM, demonstrating low membrane permeability and minimal toxicity to Ovcar-8 and MCF-10A cells, with IC50 values of 12.66 µM and 11.72 µM respectively. It stabilizes hERG channel maturation without eliciting a heat shock response or degrading Hsp90alpha-dependent client proteins [1].
Molekulargewicht:
476.63
Formel:
C28H32N2O3S
Target-Kategorie:
HSP|||Potassium Channel
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
