CVN417 is an orally active antagonist of nAChR containing the alpha6 subunit, modulating phasic dopaminergic neurotransmission in an impulse-dependent fashion. It inhibits Ca(2+) efflux through nAChR subunits, displaying IC50 values of 0.086 µM (alpha6), 2.56 µM (alpha3), and 0.657 µM (alpha4). CVN417 has shown efficacy in reducing resting tremor in rodent models, suggesting a potential to ameliorate movement disorders in conditions like Parkinsons disease [1].
Target-Kategorie:
AChR|||Others
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