Nrf2-IN-3 is a mKEAP1-selective NRF2 inhibitor that selectively binds KEAP1 mutants and restores their NRF2 inhibitory function by repairing the disrupted KEAP1/NRF2 interaction, and selectively sensitizes cisplatin in xenografts of mouse mKEAP1 cancer cells.
Molekulargewicht:
442.53
Reinheit:
98.07%
CAS Nummer:
[6325-13-9]
Formel:
C22H26N4O4S
Target-Kategorie:
ROS|||Nrf2
T78841
T78841
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