BRD4 Inhibitor-28 (Compound 18), an orally active molecule, selectively inhibits the bromodomains of BRD4 (BRD4-BD1 and BRD4-BD2) with IC50 values of 15 and 55 nM, respectively. It also demonstrates inhibition of BRD2-BD1, BRD3-BD1, and BRDT-BD1 with IC50 values of 19, 25, and 68 nM, respectively. Furthermore, this compound exhibits anti-melanoma activity [1].
Molekulargewicht:
387.43
CAS Nummer:
[2468960-80-5]
Formel:
C23H21N3O3
Target-Kategorie:
Epigenetic Reader Domain
T78851
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